1. Modelling

State-of-the-art metabolic modelling
Using cutting-edge scientific developments in systems biology we create in-house computational models of microorganisms, allowing rational prediction of the required genetic modifications to produce the desired compound and its precursors.

Fast-feedback loop between strain modelling and engineering
Close collaboration between our theoretical and experimental departments allows rapid iterative optimization of the initial models based on the experimental feedback. We continuously improve our base models for future applications.

2. Genetics

Using the research databases and latest prediction tools we identify the enzymes required for the production of the target compound as well as its precursors.

The analysis of the computational models is used to predict potential metabolic bottlenecks and choke-points in the modified system and generates an optimal genetic blueprint, ready to be implemented into the micro-organism of choice.

3. Engineering

A prototype microbial cell factory (MCB) is created using the genetic modifications suggested by the model. The experimental feedback generated during the trials is used to improve and correct the initial model, speeding up the MCB optimization and upscaling process.

The second focus point is protein engineering. Bottlenecks created by ineffective enzymes are tackled using protein modelling and engineering, optimizing the structure and function of the enzymes of interest for the most effective integration into the microbial cell factory.

What others say

  • “Bacterial engineering has bright prospects for sustainable chemical products. I will be following EV Biotech closely”

    Prof. dr. Ben Feringa, Nobel Laureate Chemistry 2016
  • “After graduating from EIT-health Venturelab program, EV-biotech lead by Linda Dijkshoorn successfully develops into a competent entrepreneurial team ready for the high-tech and high-growth biotechnology field. I have high expectations about their coming success”

    Prof. dr Aard Groen Professor of Entrepreneurship at the University of Groningen and the University of Twente
  • “EV Biotech develops alternative and complementary technologies for chemical production using bacterial engineering. I am very positive about the technology and it’s potential”

    Dr. Ton Vries, Managing Director MercachemSyncom and Managing Director Groningen Campus

Research & Development

EV Biotech is currently developing a number Proof of Concept microbial cell factories for the production of high-value molecules and their precursors. Our current interests include the Biomaterials and Flavour and Fragrance markets.

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